Our high quality and experienced bioanalytical services using the powerful technique of Surface Plasmon Resonance (SPR, Biacore) provides label-free, real time analysis of a pair of interacting molecules such as small molecule drugs binding to their target proteins. In more than 15 years Biobest acquired expert knowledge in application of Biacore SPR technology and has proven to be a reliable contractor for clients from pharmaceutical, research institutions and bio-diagnostic industry in supporting their specific projects. We especially have the experiences with a number of different SPR systems, such as Biacore 2000, Biacore 3000, Biacore X100. We can ensure a rapid and professional to assist to your samples analysis with tailor designed protocols as your specific requirements.
Your advantages of using Biobest's Biacore SPR services:
- Strong expertise and knowledge in SPR technology to kinetically characterize interacting molecules
- Sufficient capacities and prompt perform your projects to obtain results in time
- Know-how in selection and validation of antibodies based on antigen and Fc receptor binding kinetics
- Determination of active concentrations using SPR-based calibration-free methods
- High sensitivity for analysing even small molecules binding to immobilized target proteins with special expertise for protein kinases
Biacore SPR services comprised
- Kinetic & affinity measurements and SOP(proteins, peptides, DNA, RNA, membranes) LMW drug screening hit validation & lead optimization
- Pre-clinical characterization and SOP of therapeutic antibodies
- ADCC (SPR assays for Fc gamma receptors CD16, CD32, CD64 and neonatal FcRn receptor interactions, C1q SPR binding assay)
- Immunoreactivity & Immunogenicity
- Pharmacokinetics & ADME (serum protein binding)
- Biacore system maintenance, optimisation, calibration and performance check Our services include work plans for stepwise assay development with flexible strategies specifically tailored to achieve your aims.
Biacore and SPR technology in Applications