The query in PubMed using Biacore as a keyword results in a total of 1515 related articles dated between 1992 and 2020 (by the date of 31 August 2020).
All titles of 1515 articles were combined together to become a corpus of about 24000 words that subsequently analyzed using Python and its related programs. A word cloud was generated as shown below that showed a visual impact of key words in relationship with Biacore technology in the real world.
The top 100 words are listed in the table below. Words appeared how many times in titles was summed as counts. The most popular word (rank number 1) is binding that showed 268 counts in 1515 titles, representing about 17.69% of total titles. This also indicates that nearly one fifth of published papers were simply investigating the binding properties. The word 'Biacore' itself only ranked 17th the most popular word with 111 counts shown in titles.
Rank | Word | Count | |
1 | binding | 268 | |
2 | surface | 262 | |
3 | plasmon | 215 | |
4 | resonance | 206 | |
5 | protein | 198 | |
6 | human | 190 | |
7 | using | 180 | |
8 | antibody | 176 | |
9 | interaction | 156 | |
10 | analysis | 153 | |
11 | receptor | 152 | |
12 | biosensor | 138 | |
13 | antibodies | 137 | |
14 | characterization | 130 | |
15 | monoclonal | 120 | |
16 | interactions | 116 | |
17 | biacore | 111 | |
18 | affinity | 100 | |
19 | factor | 97 | |
20 | growth | 81 | |
21 | proteins | 76 | |
22 | domain | 75 | |
23 | kinetic | 74 | |
24 | detection | 60 | |
25 | cell | 59 | |
26 | peptide | 59 | |
27 | virus | 58 | |
28 | novel | 55 | |
29 | activity | 54 | |
30 | functional | 53 | |
31 | cells | 52 | |
32 | identification | 46 | |
33 | recombinant | 44 | |
34 | kinetics | 42 | |
35 | specific | 42 | |
36 | technology | 42 | |
37 | antigen | 41 | |
38 | ligand | 41 | |
39 | molecular | 41 | |
40 | complex | 38 | |
41 | development | 38 | |
42 | assay | 37 | |
43 | dna | 37 | |
44 | vitro | 36 | |
45 | kinase | 35 | |
46 | acid | 35 | |
47 | singlechain | 35 | |
48 | new | 34 | |
49 | determination | 33 | |
50 | optical | 33 | |
51 | fragment | 33 | |
52 | expression | 32 | |
53 | screening | 32 | |
54 | role | 32 | |
55 | properties | 32 | |
56 | type | 32 | |
57 | targeting | 31 | |
58 | epitope | 31 | |
59 | inhibitor | 31 | |
60 | use | 30 | |
61 | spr | 30 | |
62 | coli | 30 | |
63 | inhibits | 29 | |
64 | peptides | 28 | |
65 | studies | 28 | |
66 | study | 28 | |
67 | effects | 27 | |
68 | rna | 27 | |
69 | receptors | 27 | |
70 | method | 26 | |
71 | fragments | 26 | |
72 | binds | 25 | |
73 | small | 25 | |
74 | soluble | 25 | |
75 | serum | 25 | |
76 | endothelial | 25 | |
77 | cancer | 25 | |
78 | structural | 25 | |
79 | constants | 25 | |
80 | phage | 24 | |
81 | direct | 24 | |
82 | purification | 23 | |
83 | tumor | 23 | |
84 | escherichia | 23 | |
85 | mapping | 23 | |
86 | application | 23 | |
87 | molecules | 22 | |
88 | comparison | 22 | |
89 | selection | 22 | |
90 | inhibition | 22 | |
91 | fab | 22 | |
92 | residues | 21 | |
93 | vascular | 21 | |
94 | immunoassay | 21 | |
95 | biosensors | 21 | |
96 | production | 21 | |
97 | inhibitors | 21 | |
98 | evaluation | 20 | |
99 | high | 20 | |
100 | scfv | 20 |