About 20 year in the research laboratory, the Biacore systems were evolved many new generations through technology advance. By searching Google Scholar, the publications that used one of the Biacore systems revealed the up and down of each Biacore system. The most robust system is Biacore 3000 which is still one of the most popular systems used in publications in all time. The newly generation of Biacore system, the T200 is catching up very quickly in recent years and over taking Biacore 3000 since 2016 and becoming the new most popular system in publications.