Bonna-Agela SPE products have been developed based on a thorough understanding of interactive natures of chemical molecules. Our SPE products thus can better meet customer’s needs. Our R&D results demonstrated that the adsorption/desorption property of the polymeric SPE materials are regulated by the types of the functional groups and the degree of substitution of the surface modification. In general, modification with electron donor groups will help to retain the electron-deficient molecules, while modification with electron-withdrawing groups will prefer to retain the electron-rich molecules. Different SPE materials have been developed by incorporating proper types of functional groups and the degree of substitutions on the surface, and thus providing optimized and balanced performance for all types of molecules.