Cyclic peptides can reduce the backbone flexibility of the linear peptides, therefore increase the rigidity of the molecular and limit the possible conformations of the peptides. These kinds of structural constrain is very important to the structural stability and biological activity.
Uncommon Amino Acids
- D-Amino Acid
- Aib, Abu, Ahx, Abz,β-Ala, Cit, Cha, Chg, Dab, Hyp, Har, Nle, Nva, Nal, Pyr, Orn, Phg, Sar
- Cys(tBu), Cys(Acm), Lys(Ac), Lys(Biotin), Lys(TFA)
- Seleno-Met
Special Structure Peptides
MAP (Multiple-Antigen peptide)
The main goal of the MAP is to bring small antigen peptides together in close proximity so that the molecular will have higher antigenicity which in turn gives higher antigen response.
Inter-chain disulfide
Protein Conjugation
Usually, the antigen peptides are too small to generate adequate immunological response. Therefore they need to be conjugated to a carrier protein. Most commonly used carrier proteins include KLH, BSA and OVA.
We provide the service of peptide conjugation to all above three carrier proteins.
Click Chemistry
In 2001, the term ‘‘click chemistry’’ was first coined to describe reactions defined by a set of stringent criteria: ‘‘The reaction must be modular, wide in scope, give very high yields, generate only inoffensive by-products that can be removed by non-cromatographic methods, and be stereospecific (but not necessarily enantioselective). The required process characteristics include simple reaction conditions, readily available starting materials and reagents, the use of no solvents or a solvent that is benign (such as water) or easily removed, and simple product isolation.’’