The Autobio progesterone CLIA test kit is intended for the quantitative determination of progesterone concentration in human serum.
Progesterone (Pregn-4-ene-3,20-dione) is a C21 steroid hormone. The molecular weight of this steroid hormone is 314.5. Progesterone is a female sex hormone which, in conjunction with estrogens, regulateds the accessory organs during the menstrual cycle and it is particularly important in preparing the endometrium for the implantation of the blastocyte and in maintaining pregnancy. In non-pregnant wherease in pregnancy the placenta becomes the major source. Minor sources are the adrenal cortex for bothe sexes and the testes for males.
Progesterone circulates in blood mainly bound to Corticosteroid Binding globulin (CBG), Sec Hormon Binding globulin (SHBG) and Albumin. Only 2-10% of the total concentration circulates as free hormone.
The measurements of plasma progesterone are clinically used to confirm ovulation and normal function of the corpus luteum in non-pregnant women.
Abnormal progesterone secretion has been implicated in premenstrual tension, irregular shedding of endometrium, dysmenorrhoea, and luteal insufficiency.
